@article{Pronk2022-pt,
title = {Applying the exposome concept to working life health: The EU
EPHOR project},
author = {Anjoeka Pronk and Miranda Loh and Eelco Kuijpers and Maria Albin and Jenny Selander and Lode Godderis and Manosij Ghosh and Roel Vermeulen and Susan Peters and Ingrid Sivesind Mehlum and Michelle C Turner and Vivi Schlünssen and Marcel Goldberg and Manolis Kogevinas and Barbara N Harding and Svetlana Solovieva and Tina Garani-Papadatos and Martie Tongeren and EPHOR Consortium and Rob Stierum},
year = {2022},
date = {2022-02-01},
journal = {Environ Epidemiol},
volume = {6},
number = {2},
pages = {e185},
abstract = {Exposures at work have a major impact on noncommunicable diseases
(NCDs). Current risk reduction policies and strategies are
informed by existing scientific evidence, which is limited due to
the challenges of studying the complex relationship between
exposure at work and outside work and health. We define the
working life exposome as all occupational and related
nonoccupational exposures. The latter includes nonoccupational
exposures that may be directly or indirectly influenced by or
interact with the working life of the individual in their
relation to health. The Exposome Project for Health and
Occupational Research aims to advance knowledge on the complex
working life exposures in relation to disease beyond the single
high exposure-single health outcome paradigm, mapping and
relating interrelated exposures to inherent biological pathways,
key body functions, and health. This will be achieved by
combining (1) large-scale harmonization and pooling of existing
European cohorts systematically looking at multiple exposures and
diseases, with (2) the collection of new high-resolution external
and internal exposure data. Methods and tools to characterize the
working life exposome will be developed and applied, including
sensors, wearables, a harmonized job exposure matrix (EuroJEM),
noninvasive biomonitoring, omics, data mining, and
(bio)statistics. The toolbox of developed methods and knowledge
will be made available to policy makers, occupational health
practitioners, and scientists. Advanced knowledge on working life
exposures in relation to NCDs will serve as a basis for
evidence-based and cost-effective preventive policies and
actions. The toolbox will also enable future scientists to
further expand the working life exposome knowledge base.},
keywords = {Exposome; Noncommunicable disease; Occupational; Working life},
pubstate = {published},
tppubtype = {article}
}
Exposures at work have a major impact on noncommunicable diseases
(NCDs). Current risk reduction policies and strategies are
informed by existing scientific evidence, which is limited due to
the challenges of studying the complex relationship between
exposure at work and outside work and health. We define the
working life exposome as all occupational and related
nonoccupational exposures. The latter includes nonoccupational
exposures that may be directly or indirectly influenced by or
interact with the working life of the individual in their
relation to health. The Exposome Project for Health and
Occupational Research aims to advance knowledge on the complex
working life exposures in relation to disease beyond the single
high exposure-single health outcome paradigm, mapping and
relating interrelated exposures to inherent biological pathways,
key body functions, and health. This will be achieved by
combining (1) large-scale harmonization and pooling of existing
European cohorts systematically looking at multiple exposures and
diseases, with (2) the collection of new high-resolution external
and internal exposure data. Methods and tools to characterize the
working life exposome will be developed and applied, including
sensors, wearables, a harmonized job exposure matrix (EuroJEM),
noninvasive biomonitoring, omics, data mining, and
(bio)statistics. The toolbox of developed methods and knowledge
will be made available to policy makers, occupational health
practitioners, and scientists. Advanced knowledge on working life
exposures in relation to NCDs will serve as a basis for
evidence-based and cost-effective preventive policies and
actions. The toolbox will also enable future scientists to
further expand the working life exposome knowledge base.